By B.G.J. Knols, C. Louis
Modern learn on genetic keep an eye on of disease-transmitting bugs understands varieties of scientists: those who paintings within the laboratory and people often called ‘field people’. during the last decade, either teams appear to have built differing study priorities, handle essentially diverse features in the total self-discipline of infectious-disease keep watch over, and worse, have built a systematic ‘language’ that's now not understood via the ‘other’ social gathering. This hole widens on a daily basis, among the North and the South, among ecologists and molecular biologists, geneticists and behaviourists, and so forth. the necessity to enhance a standard study time table that bridges this hole has been pointed out as a most sensible precedence by means of all events concerned. in basic terms then shall the objective of constructing applicable genetic-control innovations for vectors of ailment develop into fact. This e-book is the mirrored image of a workshop, held in Nairobi (Kenya) in July 2004. It introduced jointly a great illustration of either molecular and ecological study and, for the 1st time, integrated an important variety of researchers from disease-endemic international locations.
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Extra resources for Bridging Laboratory and Field Research for Genetic Control of Disease Vectors (Wageningen UR Frontis Series)
Integrated disease management Current state of the art Most NMCPs focus on early diagnosis and treatment, personal protection, health education and vector control. While anticipated, vaccines and GMVs are currently not available. Current vector control measures emphasize personal protection by use of ITNs or IRS, and to a lesser extent source reduction by environmental management (drainage, filling), biological control (larvivorous fish) and larviciding (Bti, Bacillus sphaericus (Bs), temephos).
The Gates Grand Challenges in Global Health initiative) accommodate vector-research components and provide new research opportunities. Future directions for research and capacity/partnership building The working group noted that this area has not received sufficient attention over the last decade, but recommended specific areas for research: • To provide proof-of-principle and biosafety assessment (risk management) of the use of GMVs for disease control by: o conducting studies on the efficacy, biosafety and risk/benefit evaluation through long-term efforts to clarify the scientific uncertainties under different experimental conditions and with the involvement of DEC investigators; o providing the basis for collection of data on vector biology, ecology, behaviour and genetics addressing efficacy and safety in the field; o developing guidelines and principles on the design and performance of efficacy and minimum-risk field research; 28 Louis and Knols • • • • • o developing criteria and test methods for environmental monitoring; o developing criteria to identify and prepare field sites for approach evaluation.
Modelling efforts should transcend simulation of events retrospectively and be more productively directed at predicting outcomes of proposed interventions. Predicting outcomes will require close collaboration among modellers, laboratory-based molecular geneticists, vector ecologists, and epidemiologists. This kind of reciprocal interaction is essential to obtain the necessary insights to advance vector-based genetic control. Complexity and generality of models will depend on their intended purpose, which will need to be determined based on interaction between the people developing models and those using their output.